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We conducted a prospective, open‐label trial to evaluate the effectiveness of a pharmacist‐based, comprehensive, smoking‐cessation program with 31 self‐referred subjects. A secondary goal was to measure changes in health‐related quality of life (HRQOL) during the cessation attempt. The program consisted of weekly, 1‐hour group sessions over 12 weeks. It incorporated nicotine replacement therapy (patch, gum) with extensive behavior modification counseling. Trained pharmacists served as program facilitators. Smoking cessation was chemically verified at 3 and 6 months by exhaled carbon monoxide. The patients' HRQOL was measured using the smoking‐cessation quality of life questionnaire at baseline, 2 weeks, and 1, 2, 3, and 6 months. Chemically verified abstinence rates at 3 and 6 months were 42% (13 patients) and 26% (8 patients), respectively. Among patients who quit, vitality, mental health, and …