作者
Ankur Gupta-Wright, Colin Kenneth Macleod, Jessica Barrett, Sarah Ann Filson, Tumena Corrah, Victoria Parris, Gurjinder Sandhu, Miriam Harris, Rachel Tennant, Nidhi Vaid, Junko Takata, Sai Duraisingham, Nemi Gandy, Harmeet Chana, Ashley Whittington, Alastair McGregor, Padmasayee Papineni
发表日期
2021/2/1
期刊
BMJ open
卷号
11
期号
2
页码范围
e047110
出版商
British Medical Journal Publishing Group
简介
Objective
To describe the characteristics and outcomes of patients with a clinical diagnosis of COVID-19 and false-negative SARS-CoV-2 reverse transcription-PCR (RT-PCR), and develop and internally validate a diagnostic risk score to predict risk of COVID-19 (including RT-PCR-negative COVID-19) among medical admissions.
Design
Retrospective cohort study.
Setting
Two hospitals within an acute NHS Trust in London, UK.
Participants
All patients admitted to medical wards between 2 March and 3 May 2020.
Outcomes
Main outcomes were diagnosis of COVID-19, SARS-CoV-2 RT-PCR results, sensitivity of SARS-CoV-2 RT-PCR and mortality during hospital admission. For the diagnostic risk score, we report discrimination, calibration and diagnostic accuracy of the model and simplified risk score and internal validation.
Results
4008 patients were admitted between 2 March and 3 May 2020. 1792 patients (44.8 …
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A Gupta-Wright, CK Macleod, J Barrett, SA Filson… - BMJ open, 2021