作者
Elvira R Shaidullina, Michael Schwabe, Thomas Rohde, Valeria V Shapovalova, Marina S Dyachkova, Alina D Matsvay, Yuliya A Savochkina, Andrey A Shelenkov, Yulia V Mikhaylova, Katharina Sydow, François Lebreton, Evgeny A Idelevich, Stefan E Heiden, Karsten Becker, Roman S Kozlov, German A Shipulin, Vasiliy G Akimkin, Michael Lalk, Sebastian Guenther, Andreas E Zautner, Jürgen A Bohnert, Ayslu M Mardanova, Ruth Bouganim, Dror Marchaim, Katharina J Hoff, Katharina Schaufler, Mikhail V Edelstein
发表日期
2023/2/13
期刊
Genome Medicine
卷号
15
期号
1
页码范围
9
出版商
BioMed Central
简介
Background
Klebsiella pneumoniae, which is frequently associated with hospital- and community-acquired infections, contains multidrug-resistant (MDR), hypervirulent (hv), non-MDR/non-hv as well as convergent representatives. It is known that mostly international high-risk clonal lineages including sequence types (ST) 11, 147, 258, and 307 drive their global spread. ST395, which was first reported in the context of a carbapenemase-associated outbreak in France in 2010, is a less well-characterized, yet emerging clonal lineage.
Methods
We computationally analyzed a large collection of K. pneumoniae ST395 genomes (n = 297) both sequenced in this study and reported previously. By applying multiple bioinformatics tools, we investigated the core-genome phylogeny and evolution of ST395 as well as distribution of accessory genome elements associated with antibiotic resistance and virulence features …
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ER Shaidullina, M Schwabe, T Rohde… - Genome Medicine, 2023