作者
Barbara Fiori, Tiziana D’Inzeo, Brunella Posteraro, Giulia Menchinelli, Flora Marzia Liotti, Giulia De Angelis, Flavio De Maio, Massimo Fantoni, Rita Murri, Giancarlo Scoppettuolo, Giulio Ventura, Mario Tumbarello, Francesco Pennestrì, Francesco Taccari, Maurizio Sanguinetti, Teresa Spanu
发表日期
2019/5/3
期刊
Infection and drug resistance
页码范围
1055-1062
出版商
Taylor & Francis
简介
Objectives
To describe a rapid workflow based on the direct detection of Escherichia coli (Ec) and Klebsiella pneumoniae (Kp) producing CTX-M extended-spectrum β-lactamase (ESBL) and/or carbapenemases (eg, KPC, VIM) from blood cultures (BCs) and the infectious disease (ID) consulting for timely appropriate antimicrobial therapy.
Methods
This observational, retrospective study included adult patients with a first episode of Ec or Kp bloodstream infection (BSI) in a large Italian university hospital, where an inpatient ID consultation team (IDCT) has been operational. Results from the BCs tested for detecting blaCTX-M, blaKPC, blaNDM, blaOXA-48-like, and blaVIM genes by the eazyplex® SuperBug CRE assay in Ec and Kp organisms had been notified for antimicrobial therapy consulting.
Results
In 321 BSI episodes studied, we found that 151 (47.0%) of Ec or Kp organisms harbored blaCTX-M and/or blaKPC …
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B Fiori, T D'Inzeo, B Posteraro, G Menchinelli, FM Liotti… - Infection and drug resistance, 2019