作者
Catherine M Cahill, Anna MW Taylor
发表日期
2017/2/1
来源
Current opinion in behavioral sciences
卷号
13
页码范围
171-177
出版商
Elsevier
简介
Highlights
- Neuroinflammation in limbic structures co-occurs in both chronic pain and opioid dependence.
- Major depressive disorder is associated with neuroinflammation.
- Chronic pain and chronic opioid regimens blunt drug-induced reward.
- Inhibiting microglial activation restores blunted reward.
Chronic pain is a disease that encompasses both sensory and emotional elements. Opioids are highly effective analgesics because they target both of these elements, by inhibiting pain pathways and alleviating negative affect (including depression) by engaging reward or hedonic pathways. Unfortunately, chronic opioid use is limited by the development of unwanted side effects, such as tolerance, hyperalgesia, and abuse liability. Thus, the challenge of providing effective pain treatment while minimizing these unwanted side effects is an ongoing issue with significant clinical and societal impact. In this review, we posit that …
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CM Cahill, AMW Taylor - Current opinion in behavioral sciences, 2017