作者
Richa Rai, Shalini S Yadav, Heng Pan, Irtaza Khan, James O'Connor, Mohammed Alshalalfa, Elai Davicioni, Emanuela Taioli, Olivier Elemento, Ashutosh K Tewari, Kamlesh K Yadav
发表日期
2019/4
期刊
Cancer Reports
卷号
2
期号
2
页码范围
e1153
简介
Background
Prostate cancer (PCa) is the second most leading cause of death in men worldwide. African‐American men (AA) represent more aggressive form of the disease compared to Caucasian (CA) counterparts. Several lines of evidences suggest that biological factors are responsible for the observed racial disparity.
Aim
This study was aimed at identifying the epigenetic variation among AA and CA PCa patients and whether DNA methylation differences have an association with clinical outcomes in the two races.
Methods and results
The cancer genome atlas (TCGA) dataset (2015) was used to identify existing epigenetic variation in AA and CA PCa patients. Reduced Representation Bisulfite Sequencing (RRBS) was performed to identify global DNA methylation changes in a small cohort of AA and CA PCa patients. The RRBS data were then used to identify survival and recurrence outcomes in AA and …
学术搜索中的文章
R Rai, SS Yadav, H Pan, I Khan, J O'Connor… - Cancer Reports, 2019