作者
Petra Steinacker, Emily Feneberg, Jochen Weishaupt, Johannes Brettschneider, Hayrettin Tumani, Peter M Andersen, Christine AF von Arnim, Sarah Böhm, Jan Kassubek, Christian Kubisch, Dorothée Lulé, Hans-Peter Müller, Rainer Muche, Elmar Pinkhardt, Patrick Oeckl, Angela Rosenbohm, Sarah Anderl-Straub, Alexander E Volk, Patrick Weydt, Albert C Ludolph, Markus Otto
发表日期
2016/1/1
期刊
Journal of Neurology, Neurosurgery & Psychiatry
卷号
87
期号
1
页码范围
12-20
出版商
BMJ Publishing Group Ltd
简介
Objectives
Biomarkers for the diagnosis of motoneuron diseases (MND) are urgently needed to improve the diagnostic pathway, patient stratification and monitoring. The aim of this study was to validate candidate markers for MND in cerebrospinal fluid (CSF) and specify cut-offs based on large patient cohorts by especially considering patients who were seen under the initial differential diagnosis (MND mimics).
Methods
In a prospective study, we investigated CSF of 455 patients for neurofilament light chain (NfL), phosphorylated heavy chain (pNfH), tau protein (Tau) and phospho-tau protein (pTau). Analysed cohorts included patients with apparently sporadic and familial amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) (MND, n=253), MND mimics (n=85) and neurological control groups. Cut-off values were specified, and diagnostic performance and correlation with progression were analysed …
学术搜索中的文章
P Steinacker, E Feneberg, J Weishaupt… - Journal of Neurology, Neurosurgery & Psychiatry, 2016