作者
Emanuele Di Angelantonio, Simon G Thompson, Stephen Kaptoge, Carmel Moore, Matthew Walker, Jane Armitage, Willem H Ouwehand, David J Roberts, John Danesh, Jenny Donovan, Ian Ford, Rachel Henry, Beverley J Hunt, Bridget Le Huray, Susan Mehenny, Gail Miflin, Jane Green, Mike Stredder, Nicholas A Watkins, Alan McDermott, Clive Ronaldson, Claire Thomson, Zoe Tolkien, Lorna Williamson, David Allen, Jennifer Sambrook, Tracey Hammerton, David Bruce, Fizzah Choudry, Cedric Ghevaert, Kirstie Johnston, Anne Kelly, Andrew King, Alfred Mo, Lizanne Page, Penny Richardson, Peter Senior, Yagnesh Umrania, Henna Wong, Gavin Murphy, Adrian C Newland, Keith Wheatley, Michael Greaves, Marc Turner, Tahir Aziz, Richard Brain, Christine Davies, Ruth Turner, Paula Wakeman, Alison Dent, Alan Wakeman, Ben Anthony, Desmond Bland, Will Parrondo, Helen Vincent, Candy Weatherill, Andrea Forsyth, Carol Butterfield, Tracey Wright, Karen Ellis, Pat Poynton, Carolyn Brooks, Emma Martin, Lara Littler, Lindsay Williams, Donna Blair, Karen Ackerley, Lynn Woods, Sophie Stanley, Gemma Walsh, Gayle Franklin, Cheryl Howath, Sarah Sharpe, Deborah Smith, Lauren Botham, Caroline Williams, Claire Alexander, Gareth Sowerbutts, Diane Furnival, Michael Thake, Shilpa Patel, Carolyn Roost, Sandra Sowerby, Mary Joy Appleton, Eileen Bays, Geoff Bowyer, Steven Clarkson, Stuart Halson, Kate Holmes, Gareth Humphries, Lee Parvin-Cooper, Jason Towler, Joanne Addy, Patricia Barrass, Louise Stennett, Susan Burton, Hannah Dingwall, Victoria Clarke, Maria Potton, Thomas Bolton, Michael Daynes, Sarah Spackman, Abudu Momodu, James Fenton, Adam King, Omer Muhammed, Nicholas Oates, Tim Peakman, Christine Ryan, Kristian Spreckley, Craig Stubbins, Joanna Williams, James Brennan, Cedric Mochon, Samantha Taylor, Kimberley Warren, Jonathan Mant
发表日期
2017/11/25
期刊
The Lancet
卷号
390
期号
10110
页码范围
2360-2371
出版商
Elsevier
简介
Background
Limits on the frequency of whole blood donation exist primarily to safeguard donor health. However, there is substantial variation across blood services in the maximum frequency of donations allowed. We compared standard practice in the UK with shorter inter-donation intervals used in other countries.
Methods
In this parallel group, pragmatic, randomised trial, we recruited whole blood donors aged 18 years or older from 25 centres across England, UK. By use of a computer-based algorithm, men were randomly assigned (1:1:1) to 12-week (standard) versus 10-week versus 8-week inter-donation intervals, and women were randomly assigned (1:1:1) to 16-week (standard) versus 14-week versus 12-week intervals. Participants were not masked to their allocated intervention group. The primary outcome was the number of donations over 2 years. Secondary outcomes related to safety were quality of life …
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E Di Angelantonio, SG Thompson, S Kaptoge, C Moore… - The Lancet, 2017