作者
Alexander P Vlaar, Simon Oczkowski, Sanne de Bruin, Marije Wijnberge, Massimo Antonelli, Cecile Aubron, Philippe Aries, Jacques Duranteau, Nicole P Juffermans, Jens Meier, Gavin J Murphy, Riccardo Abbasciano, Marcella Muller, Akshay Shah, Anders Perner, Sofie Rygaard, Timothy S Walsh, Gordon Guyatt, JC Dionne, Maurizio Cecconi
发表日期
2020/4
期刊
Intensive care medicine
卷号
46
页码范围
673-696
出版商
Springer Berlin Heidelberg
简介
Objective
To develop evidence-based clinical practice recommendations regarding transfusion practices in non-bleeding, critically ill adults.
Design
A task force involving 13 international experts and three methodologists used the GRADE approach for guideline development.
Methods
The task force identified four main topics: red blood cell transfusion thresholds, red blood cell transfusion avoidance strategies, platelet transfusion, and plasma transfusion. The panel developed structured guideline questions using population, intervention, comparison, and outcomes (PICO) format.
Results
The task force generated 16 clinical practice recommendations (3 strong recommendations, 13 conditional recommendations), and identified five PICOs with insufficient evidence to make any …
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AP Vlaar, S Oczkowski, S de Bruin, M Wijnberge… - Intensive care medicine, 2020