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Over the last few decades, biomaterials became excellent candidates for tissue engineering applications. Several biomaterials including scaffolds and hydrogels have been reported in cardiovascular and orthopedic-related medical conditions. However, their applications in gynecology are very limited. With this aim, the proposed review article exhibits the importance of biomaterials, such as alginate, chitosan, collagen, and fibrin-based hydrogels and 3D scaffolds for tissue engineering in female reproductive organs. These biomaterials have previously been reported in the functionalization of the nano-drug delivery system for targeted delivery. However, their role directly as therapeutic molecules is a new area under study and has not been studied in detail in Polycystic Ovarian Syndrome (PCOS). Therefore, here we summarized the importance and applications of biomaterials in regenerative medicine for PCOS …