作者
Sanjay Mishra, Manish Charan, Rajni Kant Shukla, Pranay Agarwal, Swati Misri, Ajeet K Verma, Dinesh K Ahirwar, Jalal Siddiqui, Kirti Kaul, Neety Sahu, Kunj Vyas, Ayush Arpit Garg, Anum Khan, Wayne O Miles, Jonathan W Song, Nidhi Bhutani, Ramesh K Ganju
发表日期
2022/2/8
期刊
Journal of Experimental & Clinical Cancer Research
卷号
41
期号
1
页码范围
54
出版商
BioMed Central
简介
Background
Molecular mechanisms underlying inflammation-associated breast tumor growth are poorly studied. S100A7, a pro-inflammatory molecule has been shown to enhance breast cancer growth and metastasis. However, the S100A7-mediated molecular mechanisms in enhancing tumor growth and metastasis are unclear.
Methods
Human breast cancer tissue and plasma samples were used to analyze the expression of S100A7, cPLA2, and PGE2. S100A7-overexpressing or downregulated human metastatic breast cancer cells were used to evaluate the S100A7-mediated downstream signaling mechanisms. Bi-transgenic mS100a7a15 overexpression, TNBC C3 (1)/Tag transgenic, and humanized patient-derived xenograft mouse models and cPLA2 inhibitor (AACOCF3) were used to investigate the role of S100A7/cPLA2/PGE2 signaling in tumor growth and metastasis. Additionally, CODEX, a highly …
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S Mishra, M Charan, RK Shukla, P Agarwal, S Misri… - Journal of Experimental & Clinical Cancer Research, 2022