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Reduced injected doses in PET examinations result in lower radiation exposure, reduced acquisition times, reduced costs for institutions and ethically allow for additional scans within the same subject. Previous research has demonstrated that the injected dose of several different PET tracers can be reduced without substantial effects on quantitative outcome measures. Here, we studied the effect of reduced injected doses on signal‐to‐noise ratios (SNRs) and standardised uptake value ratios (SUVRs) for the FDA‐approved amyloid‐β (Aβ) PET tracer [¹⁸F]flutemetamol.

Thirty [¹⁸F]flutemetamol PET scans from previously classified Aβ‐positive and Aβ‐negative individuals were included in this study (Table 1). Amyloid positivity was derived using a validated centiloid pipeline. Subsets of the PET data containing 70%, 50%, 40% 30% and 20% of the total events was extracted randomly from the …