作者
M Vamsi Krishna, Rajendra N Dash, P Venugopal, B Jalachandra Reddy, P Sandeep, G Madhavi
发表日期
2017/1/1
期刊
Journal of Saudi Chemical Society
卷号
21
期号
1
页码范围
1-10
出版商
Elsevier
简介
An isocratic RP-HPLC–UV method for the analysis of voriconazole in skin diffusate samples has been developed and validated. Experimental design was employed to optimize the method. The method was validated as per ICH guidelines. Linearity was observed over the concentration range of 2–100 μg mL−1 (r2 = 0.999). Limits of detection and quantification were 0.6 and 2 μg mL−1, respectively. Intra-day and inter-day precision (% RSD) was within the ICH limits (⩽2%). The method was successfully used to analyze skin diffusate samples, and the effectiveness of different permeation enhancers was compared with respect to flux and permeability coefficient.
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MV Krishna, RN Dash, P Venugopal, BJ Reddy… - Journal of Saudi Chemical Society, 2017