作者
Mia Hashibe, Paul Brennan, Shu-chun Chuang, Stefania Boccia, Xavier Castellsague, Chu Chen, Maria Paula Curado, Luigino Dal Maso, Alexander W Daudt, Eleonora Fabianova, Leticia Fernandez, Victor Wünsch-Filho, Silvia Franceschi, Richard B Hayes, Rolando Herrero, Karl Kelsey, Sergio Koifman, Carlo La Vecchia, Philip Lazarus, Fabio Levi, Juan J Lence, Dana Mates, Elena Matos, Ana Menezes, Michael D McClean, Joshua Muscat, Jose Eluf-Neto, Andrew F Olshan, Mark Purdue, Peter Rudnai, Stephen M Schwartz, Elaine Smith, Erich M Sturgis, Neonilia Szeszenia-Dabrowska, Renato Talamini, Qingyi Wei, Deborah M Winn, Oxana Shangina, Agnieszka Pilarska, Zuo-Feng Zhang, Gilles Ferro, Julien Berthiller, Paolo Boffetta
发表日期
2009/2/1
期刊
Cancer Epidemiology Biomarkers & Prevention
卷号
18
期号
2
页码范围
541-550
出版商
American Association for Cancer Research
简介
Background: The magnitude of risk conferred by the interaction between tobacco and alcohol use on the risk of head and neck cancers is not clear because studies have used various methods to quantify the excess head and neck cancer burden.
Methods: We analyzed individual-level pooled data from 17 European and American case-control studies (11,221 cases and 16,168 controls) participating in the International Head and Neck Cancer Epidemiology consortium. We estimated the multiplicative interaction parameter (ψ) and population attributable risks (PAR).
Results: A greater than multiplicative joint effect between ever tobacco and alcohol use was observed for head and neck cancer risk (ψ = 2.15; 95% confidence interval, 1.53-3.04). The PAR for tobacco or alcohol was 72% (95% confidence interval, 61-79%) for head and neck cancer, of which 4% was due to alcohol alone, 33% was due to …
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M Hashibe, P Brennan, S Chuang, S Boccia… - Cancer Epidemiology Biomarkers & Prevention, 2009