作者
Nicholas J Shaheen, Prateek Sharma, Bergein F Overholt, Herbert C Wolfsen, Richard E Sampliner, Kenneth K Wang, Joseph A Galanko, Mary P Bronner, John R Goldblum, Ana E Bennett, Blair A Jobe, Glenn M Eisen, M Brian Fennerty, John G Hunter, David E Fleischer, Virender K Sharma, Robert H Hawes, Brenda J Hoffman, Richard I Rothstein, Stuart R Gordon, Hiroshi Mashimo, Kenneth J Chang, V Raman Muthusamy, Steven A Edmundowicz, Stuart J Spechler, Ali A Siddiqui, Rhonda F Souza, Anthony Infantolino, Gary W Falk, Michael B Kimmey, Ryan D Madanick, Amitabh Chak, Charles J Lightdale
发表日期
2009/5/28
期刊
New England Journal of Medicine
卷号
360
期号
22
页码范围
2277-2288
出版商
Massachusetts Medical Society
简介
Background
Barrett's esophagus, a condition of intestinal metaplasia of the esophagus, is associated with an increased risk of esophageal adenocarcinoma. We assessed whether endoscopic radiofrequency ablation could eradicate dysplastic Barrett's esophagus and decrease the rate of neoplastic progression.
Methods
In a multicenter, sham-controlled trial, we randomly assigned 127 patients with dysplastic Barrett's esophagus in a 2:1 ratio to receive either radiofrequency ablation (ablation group) or a sham procedure (control group). Randomization was stratified according to the grade of dysplasia and the length of Barrett's esophagus. Primary outcomes at 12 months included the complete eradication of dysplasia and intestinal metaplasia.
Results
In the intention-to-treat analyses, among patients with low-grade dysplasia, complete eradication of dysplasia occurred in 90.5% of those in the ablation group, as …
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