作者
Cheng Peng, Marie-Abele C Bind, Elena Colicino, Itai Kloog, Hyang-Min Byun, Laura Cantone, Letizia Trevisi, Jia Zhong, Kasey Brennan, Alexandra E Dereix, Pantel S Vokonas, Brent A Coull, Joel D Schwartz, Andrea A Baccarelli
发表日期
2016/11
期刊
Environmental health perspectives
卷号
124
期号
11
页码范围
1715-1721
出版商
National Institute of Environmental Health Sciences
简介
Background
Among nondiabetic individuals, higher fasting blood glucose (FBG) independently predicts diabetes risk, cardiovascular disease, and dementia. Ambient PM2.5 (particulate matter with aerodynamic diameter ≤ 2.5 μm) is an emerging determinant of glucose dysregulation. PM2.5 effects and mechanisms are understudied among nondiabetic individuals.
Objectives
Our goals were to investigate whether PM2.5 is associated with an increase in FBG and to explore potential mediating roles of epigenetic gene regulation.
Methods
In 551 nondiabetic participants in the Normative Aging Study, we measured FBG, and DNA methylation of four inflammatory genes (IFN-γ, IL-6, ICAM-1, and TLR-2), up to four times between 2000 and 2011 (median = 2). We estimated short- and medium-term (1-, 7-, and 28-day preceding each clinical visit) ambient PM2.5 at each participant’s address using a validated hybrid land …
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C Peng, MAC Bind, E Colicino, I Kloog, HM Byun… - Environmental health perspectives, 2016