作者
Michele Dipalo, Giovanni Melle, Laura Lovato, Andrea Jacassi, Francesca Santoro, Valeria Caprettini, Andrea Schirato, Alessandro Alabastri, Denis Garoli, Giulia Bruno, Francesco Tantussi, Francesco De Angelis
发表日期
2018/10
期刊
Nature nanotechnology
卷号
13
期号
10
页码范围
965-971
出版商
Nature Publishing Group
简介
The ability to monitor electrogenic cells accurately plays a pivotal role in neuroscience, cardiology and cell biology. Despite pioneering research and long-lasting efforts, the existing methods for intracellular recording of action potentials on the large network scale suffer limitations that prevent their widespread use. Here, we introduce the concept of a meta-electrode, a planar porous electrode that mimics the optical and biological behaviour of three-dimensional plasmonic antennas but also preserves the ability to work as an electrode. Its synergistic combination with plasmonic optoacoustic poration allows commercial complementary metal–oxide semiconductor multi-electrode arrays to record intracellular action potentials in large cellular networks. We apply this approach to measure signals from human-induced pluripotent stem cell-derived cardiac cells, rodent primary cardiomyocytes and immortalized cell types …
引用总数
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