作者
Patrick F Connolly, Richard Jäger, Howard O Fearnhead
发表日期
2014/4/16
来源
Frontiers in physiology
卷号
5
页码范围
79040
出版商
Frontiers
简介
It has become increasingly clear that caspases, far from being merely cell death effectors, have a much wider range of functions within the cell. These functions are as diverse as signal transduction and cytoskeletal remodeling, and caspases are now known to have an essential role in cell proliferation, migration, and differentiation. There is also evidence that apoptotic cells themselves can direct the behavior of nearby cells through the caspase-dependent secretion of paracrine signaling factors. In some processes, including the differentiation of skeletal muscle myoblasts, both caspase activation in differentiating cells as well as signaling from apoptotic cells has been reported. Here, we review the non-apoptotic outcomes of caspase activity in a range of different model systems and attempt to integrate this knowledge.
学术搜索中的文章
PF Connolly, R Jäger, HO Fearnhead - Frontiers in physiology, 2014