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Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 (AT₁ ) receptor blockers improve ischemia–reperfusion induced arrhythmias and infarct size in several animal models. However, the effects of pretreatment with ACEIs or AT ₁receptor blockers on acute myocardial infarct size and arrhythmias are controversial. Thus, we sought to assess the comparative effects of pretreatment with ACEI captopril and AT₁ -receptor blocker losartan on myocardial infarct size and arrhythmias in a rat model of ischemia-reperfusion. We randomly assigned 92 male Wistar rats for arrhythmias ( n= 60) and necrosis ( n= 32) experiments. To produce arrhythmia, the left main coronary artery was occluded for 7 min, followed by 7 min of reperfusion and to produce necrosis, the the left main coronary artery was occluded for 30 min, followed by 120 min of reperfusion. Captopril (3 mg kg ⁻¹) and losartan (0.2 and 2 mg kg …