作者
Seymour Garte, Laura Gaspari, Anna-Karin Alexandrie, Christine Ambrosone, Herman Autrup, Judith L Autrup, Helena Baranova, Lise Bathum, Simone Benhamou, Paolo Boffetta, Christine Bouchardy, Katja Breskvar, Jurgen Brockmoller, Ingolf Cascorbi, Margie L Clapper, Christiane Coutelle, Ann Daly, Marco Dell’Omo, Vita Dolzan, Carolyn M Dresler, Anthony Fryer, Aage Haugen, David W Hein, Allan Hildesheim, Ari Hirvonen, Ling-Ling Hsieh, Magnus Ingelman-Sundberg, Ivan Kalina, Daehee Kang, Masahiro Kihara, Chikako Kiyohara, Pierre Kremers, Philip Lazarus, Loïc Le Marchand, Maria Celeste Lechner, Ester MM van Lieshout, Stephanie London, Johannes J Manni, Christine M Maugard, Shunji Morita, Valle Nazar-Stewart, Kazumasa Noda, Yoshio Oda, Fritz F Parl, Roberta Pastorelli, Irene Persson, Wilbert HM Peters, Agneta Rannug, Timothy Rebbeck, Angela Risch, Liliane Roelandt, Marjorie Romkes, David Ryberg, Jan Salagovic, Bernadette Schoket, Janeric Seidegard, Peter G Shields, Edith Sim, Daniel Sinnet, Richard C Strange, Isabel Stücker, Haruhiko Sugimura, Jordi To-Figueras, Paolo Vineis, Mimi C Yu, Emanuela Taioli
发表日期
2001/12/1
期刊
Cancer Epidemiology Biomarkers & Prevention
卷号
10
期号
12
页码范围
1239-1248
出版商
American Association for Cancer Research
简介
Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15,000 control (noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes (CYP1A1, CYP2E1, CYP2D6, GSTM1, GSTT1, NAT2, GSTP, and EPHX) in the human population were determined. Major and significant differences in these frequencies were observed between Caucasians (n = 12,525), Asians (n = 2,136), and Africans and African Americans (n = 996), and some, but much less, heterogeneity was observed within Caucasian populations from different countries. No differences in allele frequencies were seen by age, sex, or type of controls (hospital patients versus population controls). No examples of linkage disequilibrium between the different loci were detected based on comparison of observed and expected …
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S Garte, L Gaspari, AK Alexandrie, C Ambrosone… - Cancer Epidemiology Biomarkers & Prevention, 2001