作者
Sheila A Bingham, Nicholas E Day, Robert Luben, Pietro Ferrari, Nadia Slimani, Teresa Norat, Françoise Clavel-Chapelon, Emmanuelle Kesse, Alexandra Nieters, Heiner Boeing, Anne Tjϕnneland, Kim Overvad, Carmen Martinez, Miren Dorronsoro, Carlos A Gonzalez, Timothy J Key, Antonia Trichopoulou, Androniki Naska, Paolo Vineis, Rosario Tumino, Vittorio Krogh, H Bas Bueno-de-Mesquita, Petra HM Peeters, Göran Berglund, Göran Hallmans, Eiliv Lund, Guri Skeie, Rudolf Kaaks, Elio Riboli
发表日期
2003/5/3
期刊
The lancet
卷号
361
期号
9368
页码范围
1496-1501
出版商
Elsevier
简介
Background
Dietary fibre is thought to protect against colorectal cancer but this view has been challenged by recent prospective and intervention studies that showed no protective effect.
Methods
We prospectively examined the association between dietary fibre intake and incidence of colorectal cancer in 519 978 individuals aged 25–70 years taking part in the EPIC study, recruited from ten European countries. Participants completed a dietary questionnaire in 1992–98 and were followed up for cancer incidence. Relative risk estimates were obtained from fibre intake, categorised by sex-specific, cohort-wide quintiles, and from linear models relating the hazard ratio to fibre intake expressed as a continuous variable.
Findings
Follow-up consisted of 1 939 011 person-years, and data for 1065 reported cases of colorectal cancer were included in the analysis. Dietary fibre in foods was inversely related to incidence of …
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SA Bingham, NE Day, R Luben, P Ferrari, N Slimani… - The lancet, 2003