作者
Tobias Pischon, Heiner Boeing, Katrin Hoffmann, M Bergmann, Matthias B Schulze, K Overvad, YT Van Der Schouw, E Spencer, KGM Moons, A Tjønneland, J Halkjaer, MK Jensen, Jakob Stegger, F Clavel-Chapelon, M-C Boutron-Ruault, V Chajes, Jakob Linseisen, R Kaaks, A Trichopoulou, D Trichopoulos, C Bamia, S Sieri, D Palli, R Tumino, Paolo Vineis, Salvatore Panico, PHM Peeters, AM May, HB Bueno-de-Mesquita, FJB Van Duijnhoven, Göran Hallmans, Lars Weinehall, Jonas Manjer, Bo Hedblad, E Lund, A Agudo, L Arriola, A Barricarte, C Navarro, C Martinez, JR Quirós, T Key, S Bingham, KT Khaw, P Boffetta, M Jenab, P Ferrari, E Riboli
发表日期
2008/11/13
期刊
New England Journal of Medicine
卷号
359
期号
20
页码范围
2105-2120
出版商
Massachusetts Medical Society
简介
Background
Previous studies have relied predominantly on the body-mass index (BMI, the weight in kilograms divided by the square of the height in meters) to assess the association of adiposity with the risk of death, but few have examined whether the distribution of body fat contributes to the prediction of death.
Methods
We examined the association of BMI, waist circumference, and waist-to-hip ratio with the risk of death among 359,387 participants from nine countries in the European Prospective Investigation into Cancer and Nutrition (EPIC). We used a Cox regression analysis, with age as the time variable, and stratified the models according to study center and age at recruitment, with further adjustment for educational level, smoking status, alcohol consumption, physical activity, and height.
Results
During a mean follow-up of 9.7 years, 14,723 participants died. The lowest risks of death related to BMI were …
引用总数
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