作者
Barbara B Warner, Elena Deych, Yanjiao Zhou, Carla Hall-Moore, George M Weinstock, Erica Sodergren, Nurmohammad Shaikh, Julie A Hoffmann, Laura A Linneman, Aaron Hamvas, Geetika Khanna, Lucina C Rouggly-Nickless, I Malick Ndao, Berkley A Shands, Marilyn Escobedo, Janice E Sullivan, Paula G Radmacher, William D Shannon, Phillip I Tarr
发表日期
2016/5/7
期刊
The Lancet
卷号
387
期号
10031
页码范围
1928-1936
出版商
Elsevier
简介
Background
Gut bacteria might predispose to or protect from necrotising enterocolitis, a severe illness linked to prematurity. In this observational prospective study we aimed to assess whether one or more bacterial taxa in the gut differ between infants who subsequently develop necrotising enterocolitis (cases) and those who do not (controls).
Methods
We enrolled very low birthweight (1500 g and lower) infants in the primary cohort (St Louis Children's Hospital) between July 7, 2009, and Sept 16, 2013, and in the secondary cohorts (Kosair Children's Hospital and Children's Hospital at Oklahoma University) between Sept 12, 2011 and May 25, 2013. We prospectively collected and then froze stool samples for all infants. Cases were defined as infants whose clinical courses were consistent with necrotising enterocolitis and whose radiographs fulfilled criteria for Bell's stage 2 or 3 necrotising enterocolitis. Control …
学术搜索中的文章
BB Warner, E Deych, Y Zhou, C Hall-Moore… - The Lancet, 2016