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In vitro models are becoming more advanced to truly present physiological systems while enabling high‐throughput screening and analysis. Organ‐on‐a‐chip devices provide remarkable results through the reconstruction of a three‐dimensional (3D) cellular microenvironment although they need to be further developed in terms of multiple liquid patterning principle, material properties, and scalability. Here we present a 3D anchor‐based microfluidic injection‐molded plastic array culture platform (Anchor‐IMPACT) that enables selective, space‐intensive patterning of hydrogels using anchor‐island for high‐throughput angiogenesis evaluation model. Anchor‐IMPACT consists of a central channel and an anchor‐island, integrating the array into an abbreviated 96‐well plate format with a standard microscope slide size. The anchor‐island enables selective 3D cell patterning without channel‐to‐channel contact or …