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One of the most important problems developing in patients who have undergone thyroidectomy is hypocalcemia. For this reason, the calcium (Ca) level is screened in patients, but it is not routinely screened for low levels of 25-hydroxy vitamin D3 (25-OH D3), which is found to be associated with many diseases in the postoperative mid-period, in normocalcemic patients who have undergone thyroidectomy.

The study included 60 normocalcemic patients (Group 1) who underwent thyroidectomy due to nodular goiter and 170 patients (Group 2) who applied with the suspicion of thyroid disease and who were evaluated as normal and who did not receive Ca and 25-OH D3 supplements (Group 2). Biochemical hypocalcemia was defined as a corrected Ca level of less than 8.0 mg/dL. 25-OH D3 levels of all patients at the postoperative 12th month were recorded by scanning their Ca levels and routine laboratory tests.

Measurements were made in 12th month postoperatively. The 25-OH D3 levels of the patients in Group 1 were lower than the 25-OH D3 lev els of the patients in Group 2 (p<0.001). The thyroxine (T4) hormone levels of the patients in Group 1 were higher than the T4 values of the patients in Group 2 (p=0.002). There was no statistically significant difference between the Ca levels of the patients in Group 1 and Group 2. (p>0.05). There was no difference between other measurement parameters.

We think that in patients who underwent thyroidectomy due to nodular goiter, their 25-OH D3 levels should be screened in the postoperative period and replaced if necessary.