作者
Alexandre Lopez, Ines Lakbar, Louis Delamarre, Aurelien Culver, Charlotte Arbelot, Gary Duclos, Emmanuelle Hammad, Bruno Pastene, Francois Antonini, Laurent Zieleskiewicz, Marc Leone
发表日期
2021/10/1
期刊
Journal of critical care
卷号
65
页码范围
200-204
出版商
WB Saunders
简介
Purpose
To compare the effects of two therapeutic bundles of management in SARS-CoV2 ICU patients.
Materials and methods
Our retrospective, observational study was performed in a university ICU from March to June 2020 (first wave) and from September 2020 to January 2021 (second wave). In first wave, patients received bundle 1 including early invasive ventilation, hydroxychloroquine, cefotaxime and azithromycin. In second wave, bundle 2 included non-invasive oxygenation support and dexamethasone. The main outcome was in-hospital mortality. Secondary outcomes included ICU and hospital length of stay, ICU supportive therapies, viral clearance and antimicrobial resistance emergence.
Results
129 patients with SARS-CoV-2 pneumonia were admitted to our ICU. Thirty-five were treated according to bundle 1 and 76 to bundle 2. In-hospital mortality was similar in the two groups (23%, p = 1). The …
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A Lopez, I Lakbar, L Delamarre, A Culver, C Arbelot… - Journal of critical care, 2021