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PostScript revealed symmetrical background activity of low-voltage delta waves without spatial organisation, triphasic waves or paroxysmal activity. He showed unresponsive coma (Glasgow Coma Scale= 3), pyramidal syndrome, rightsided sixth nerve palsy and no corneal reflex. A second brain contrast-enhanced MRI at day 22 revealed progressing lesions with diffuse hyperintense lesions in the thalami, cerebellum, brainstem, supratentorial grey and white matters on FLAIR images without gadoliniumenhanced lesions (figure 1). At this time, the patient no longer had respiratory viral excretion (two negative RT-PCR at 48-hour interval on tracheal aspirations). A second CSF sampling revealed no meningitic cytological pattern and PCR results were negative for SARS-CoV-2 and other common viruses (online supplementar y material). Anti-ganglioside autoantibodies were not found in patient’s serum (immunodot …