作者
Katy ME Turner, Sharon Hutchinson, Peter Vickerman, Vivian Hope, Noel Craine, Norah Palmateer, Margaret May, Avril Taylor, Daniela De Angelis, Sheila Cameron, John Parry, Margaret Lyons, David Goldberg, Elizabeth Allen, Matthew Hickman
发表日期
2011/11/1
期刊
Addiction
卷号
106
期号
11
页码范围
1978-1988
出版商
Blackwell Publishing Ltd
简介
Aims To investigate whether opiate substitution therapy (OST) and needle and syringe programmes (NSP) can reduce hepatitis C virus (HCV) transmission among injecting drug users (IDUs).
Design Meta‐analysis and pooled analysis, with logistic regression allowing adjustment for gender, injecting duration, crack injecting and homelessness.
Setting Six UK sites (Birmingham, Bristol, Glasgow, Leeds, London and Wales), community recruitment.
Participants A total of 2986 IDUs surveyed during 2001–09.
Measurement Questionnaire responses were used to define intervention categories for OST (on OST or not) and high NSP coverage (≥100% versus <100% needles per injection). The primary outcome was new HCV infection, measured as antibody seroconversion at follow‐up or HCV antibody‐negative/RNA‐positive result in cross‐sectional surveys.
Findings Preliminary meta‐analysis showed little …
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KME Turner, S Hutchinson, P Vickerman, V Hope… - Addiction, 2011