作者
Koichi Node, Yuqing Huo, Xiulu Ruan, Baichun Yang, Martin Spiecker, Klaus Ley, Darryl C Zeldin, James K Liao
发表日期
1999/8/20
期刊
Science
卷号
285
期号
5431
页码范围
1276-1279
出版商
American Association for the Advancement of Science
简介
The epoxyeicosatrienoic acids (EETs) are products of cytochrome P450 epoxygenases that have vasodilatory properties similar to that of endothelium-derived hyperpolarizing factor. The cytochrome P450 isoform CYP2J2 was cloned and identified as a potential source of EETs in human endothelial cells. Physiological concentrations of EETs or overexpression of CYP2J2 decreased cytokine-induced endothelial cell adhesion molecule expression, and EETs prevented leukocyte adhesion to the vascular wall by a mechanism involving inhibition of transcription factor NF-κB and IκB kinase. The inhibitory effects of EETs were independent of their membrane-hyperpolarizing effects, suggesting that these molecules play an important nonvasodilatory role in vascular inflammation.
引用总数
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K Node, Y Huo, X Ruan, B Yang, M Spiecker, K Ley… - Science, 1999