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The diagnostic performances of ultrasound (US) examination and US-guided fine needle aspiration (US-FNA) were investigated in thyroid nodules ≤10 mm in size.

From April 2006 to December 2006, 1440 nodules ≤10 mm in size in 1403 patients (mean age, 49.3 years; range, 10–84 years) underwent US and US-FNA. The association between nodule size and inadequate specimen was investigated using the Cochran-Armitage trend test and multivariate logistic regression analysis. To evaluate the diagnostic performances of US and US-FNA, we selected 852 nodules that had undergone surgery, follow-up US-FNA, or follow-up US. A receiver operating characteristic (ROC) curve analysis was used to determine the accuracies of US and US-FNA.

Of 1440 nodules, 256 (17.8%) yielded …