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Computer supported inquiry learning has become an important application of computers in education. Computers allow for providing resources for inquiry learning, such as simulations; built-in support for the processes of inquiry learning; support for collaborative learning scenarios as well as tools for modeling by learners. An overview of the main issues on research on computer supported inquiry learning is provided including issues such as assessing learning effects of computer support, gaming learning systems, as well as conditions that are favorable or detrimental to learning. The articles in the current special issue are discussed with respect to their contribution to resolving these issues.