作者
Jason A Roberts, Sanjoy K Paul, Murat Akova, Matteo Bassetti, Jan J De Waele, George Dimopoulos, Kirsi-Maija Kaukonen, Despoina Koulenti, Claude Martin, Philippe Montravers, Jordi Rello, Andrew Rhodes, Therese Starr, Steven C Wallis, Jeffrey Lipman, DALI study, Jason A Roberts, Jeffrey Lipman, Therese Starr, Steven C Wallis, Sanjoy K Paul, Antonio Margarit Ribas, Jan J De Waele, Luc De Crop, Herbert Spapen, Joost Wauters, Thierry Dugernier, Philippe Jorens, Ilse Dapper, Daniel De Backer, Fabio S Taccone, Jordi Rello, Laura Ruano, Elsa Afonso, Francisco Alvarez-Lerma, Maria Pilar Gracia-Arnillas, Francisco Fernández, Neus Feijoo, Neus Bardolet, Assumpta Rovira, Pau Garro, Diana Colon, Carlos Castillo, Juan Fernado, Maria Jesus Lopez, Jose Luis Fernandez, Ana Maria Arribas, Jose Luis Teja, Elsa Ots, Juan Carlos Montejo, Mercedes Catalan, Isidro Prieto, Gloria Gonzalo, Beatriz Galvan, Miguel Angel Blasco, Estibaliz Meyer, Frutos Del Nogal, Loreto Vidaur, Rosa Sebastian, Pila Marco Garde, Maria del Mar Martin Velasco, Rafael Zaragoza Crespo, Mariano Esperatti, Antoni Torres, Philippe Montravers, Olivier Baldesi, Herve Dupont, Yazine Mahjoub, Sigismond Lasocki, Jean Michel Constantin, Jean François Payen, Claude Martin, Jacques Albanese, Yannick Malledant, Julien Pottecher, Jean-Yves Lefrant, Samir Jaber, Olivier Joannes-Boyau, Christophe Orban, Marlies Ostermann, Cathrine McKenzie, William Berry, John Smith, Katie Lei, Francesca Rubulotta, Anthony Gordon, Stephen Brett, Martin Stotz, Maie Templeton, Andrew Rhodes, Claudia Ebm, Carl Moran, Kirsi-Maija Kaukonen, Ville Pettilä, George Dimopoulos, Despoina Koulenti, Aglaia Xristodoulou, Vassiliki Theodorou, Georgios Kouliatsis, Eleni Sertaridou, Georgios Anthopoulos, George Choutas, Thanos Rantis, Stylianos Karatzas, Margarita Balla, Metaxia Papanikolaou, Pavlos Myrianthefs, Alexandra Gavala, Antonia Koutsoukou, Magdalini Kyriakopoulou, Kalomoira Petrochilou, Maria Kompoti, Martha Michalia, Fillis-Maria Clouva-Molyvdas, Georgios Gkiokas, Fotios Nikolakopoulos, Vasiliki Psychogiou, Polychronis Malliotakis, Evangelia Akoumianaki, Emmanouil Lilitsis, Vassilios Koulouras, George Nakos, Mihalis Kalogirou, Apostolos Komnos, Tilemachos Zafeiridis, Christos Chaintoutis, Kostoula Arvaniti, Dimitrios Matamis, Christos Chaintoutis, Christina Kydona, Nikoleta Gritsi-Gerogianni, Tatiana Giasnetsova, Maria Giannakou, Ioanna Soultati, Ilias Chytas, Eleni Antoniadou, Elli Antipa, Dimitrios Lathyris, Triantafyllia Koukoubani, Theoniki Paraforou, Kyriaki Spiropoulou, Vasileios Bekos, Anna Spring, Theodora Kalatzi, Hara Nikolaou, Maria Laskou, Ioannis Strouvalis, Stavros Aloizos, Spyridon Kapogiannis, Ourania Soldatou
发表日期
2014/4/15
期刊
Clinical infectious diseases
卷号
58
期号
8
页码范围
1072-1083
出版商
Oxford University Press
简介
Background. Morbidity and mortality for critically ill patients with infections remains a global healthcare problem. We aimed to determine whether β-lactam antibiotic dosing in critically ill patients achieves concentrations associated with maximal activity and whether antibiotic concentrations affect patient outcome.
Methods. This was a prospective, multinational pharmacokinetic point-prevalence study including 8 β-lactam antibiotics. Two blood samples were taken from each patient during a single dosing interval. The primary pharmacokinetic/pharmacodynamic targets were free antibiotic concentrations above the minimum inhibitory concentration (MIC) of the pathogen at both 50% (50% f T>MIC) and 100% (100% f T>MIC) of the dosing interval. We used skewed logistic regression to describe the effect of antibiotic exposure on patient outcome …
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