作者
Rahul Aggarwal, Jiaoti Huang, Joshi J Alumkal, Li Zhang, Felix Y Feng, George V Thomas, Alana S Weinstein, Verena Friedl, Can Zhang, Owen N Witte, Paul Lloyd, Martin Gleave, Christopher P Evans, Jack Youngren, Tomasz M Beer, Matthew Rettig, Christopher K Wong, Lawrence True, Adam Foye, Denise Playdle, Charles J Ryan, Primo Lara, Kim N Chi, Vlado Uzunangelov, Artem Sokolov, Yulia Newton, Himisha Beltran, Francesca Demichelis, Mark A Rubin, Joshua M Stuart, Eric J Small
发表日期
2018/8/8
期刊
Journal of Clinical Oncology
卷号
36
期号
24
页码范围
2492
出版商
American Society of Clinical Oncology
简介
Purpose
The prevalence and features of treatment-emergent small-cell neuroendocrine prostate cancer (t-SCNC) are not well characterized in the era of modern androgen receptor (AR)–targeting therapy. We sought to characterize the clinical and genomic features of t-SCNC in a multi-institutional prospective study.
Methods
Patients with progressive, metastatic castration-resistant prostate cancer (mCRPC) underwent metastatic tumor biopsy and were followed for survival. Metastatic biopsy specimens underwent independent, blinded pathology review along with RNA/DNA sequencing.
Results
A total of 202 consecutive patients were enrolled. One hundred forty-eight (73%) had prior disease progression on abiraterone and/or enzalutamide. The biopsy evaluable rate was 79%. The overall incidence of t-SCNC detection was 17%. AR amplification and protein expression were present in 67% and 75%, respectively, of …
学术搜索中的文章
R Aggarwal, J Huang, JJ Alumkal, L Zhang, FY Feng… - Journal of Clinical Oncology, 2018