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Atrial fibrillation (AF) has been associated with a locus on chromosome 4q25 in proximity to PITX2, a gene known to regulate left/right cardiac asymmetrical morphogenesis and implicated in the formation of pulmonary vein muscle sleeve myocardium. PITX2 may also suppress a default pathway for sinoatrial node formation in the left atrium. During AF ablation, after pulmonary vein isolation (PVI) is complete, dissociated firing (DF) reminiscent of sinoatrial node activity may be observed within the pulmonary veins. We tested the hypothesis that the top previously reported genome-wide AF-associated SNP in the 4q25 locus, rs2200733, is strongly associated with the DF phenotype.

Methods: The presence of DF after PVI was identified in patients with lone AF who underwent catheter-based PVI and were enrolled in a lone AF biorepository. DNA was genotyped for rs2200733, the top previously reported AF …