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Trichosanthes dioica fruit pericarp has a powerful hypolipidemic and antioxidant properties. Wistar rats were divided into five groups (n = 30). The normal control group received vehicle and standard diet throughout the experimental period. Groups II, III, IV, and V were given a high‐fat diet and free access of water for 21 days. Experimental groups IV and V were given high‐fat diet along with T. dioica extract 400 and 800 mg/kg, respectively. Blood was collected at 21 days, and lipid profile estimation was performed. The phytochemical screening was performed by different phytochemical screening methods. Lipid peroxidation and catalase activity were done by taking a liver tissue sample. The phytochemical screening of extract showed good results and indicated the presence of phytoconstituents in extract. 2,2‐Diphenyl‐1‐picrylhydrazyl scavenging activity of T. dioica was found to be 65.79% at a concentration of …