作者
Ameeduzzafar Zafar, Nabil K Alruwaili, Syed Sarim Imam, Nasser Hadal Alotaibi, Khalid Saad Alharbi, Muhammad Afzal, Raisuddin Ali, Sultan Alshehri, Sami I Alzarea, Mohammed Elmowafy, Nabil A Alhakamy, Mohamed F Ibrahim
发表日期
2021/3/1
期刊
Saudi Pharmaceutical Journal
卷号
29
期号
3
页码范围
269-279
出版商
Elsevier
简介
Aim
Diabetic (type-2) is a metabolic disease characterized by increased blood glucose level from the normal level. In the present study, apigenin (AG) loaded lipid vesicles (bilosomes: BIL) was prepared, optimized and evaluated for the oral therapeutic efficacy.
Experimental
AG-BIL was prepared by a thin-film evaporation method using cholesterol, span 60 and sodium deoxycholate. The prepared formulation was optimized by 3-factor and 3-level Box-Behnken design using particle size, entrapment efficiency and drug release as a response. The selected formulation further evaluated for ex-vivo permeation, in vivo pharmacokinetic and pharmacodynamics study.
Results
The optimized AG bilosomes (AG-BILopt) has shown the vesicle size 183.25 ± 2.43 nm, entrapment efficiency 81.67 ± 4.87%. TEM image showed a spherical shape vesicle with sharp boundaries. The drug release study revealed a significant …
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A Zafar, NK Alruwaili, SS Imam, NH Alotaibi, KS Alharbi… - Saudi Pharmaceutical Journal, 2021