作者
Ameeduzzafar, Mohd Qumber, Nabil K Alruwaili, Syed Nasir Abbas Bukhari, Khalid Saad Alharbi, Syed Sarim Imam, Muhammad Afzal, Bader Alsuwayt, Ali Mujtaba, Asgar Ali
发表日期
2021/3
期刊
Journal of pharmaceutical innovation
卷号
16
页码范围
85-98
出版商
Springer US
简介
Objectives
The present study was aimed to develop itraconazole (ITZL)-loaded NLC for the treatment of fungal infection.
Methods
The formulation was prepared and optimized by the hot homogenization method and Box-Behnken statistical design. The total lipid ratio (A), surfactant (B), and homogenization cycle (C) were selected as independent variables, and the effects of variables were evaluated on particle size (R1), entrapment efficiency (R2), and drug release in 12 h (R3).
Results
The optimized formulation ITZLNLCopt showed particle size (147.31 ± 1.43 nm) high entrapment efficiency (86.36 ± 0.83%) and drug release (77.23 ± 3.33 %). The formulation ITZLNLCopt converted to carbopol (1% w/v) based gel (ITZLNLCopt gel) and showed good consistency and spreadability. The formulation ITZLNLCopt gel showed …
学术搜索中的文章
Ameeduzzafar, M Qumber, NK Alruwaili, SNA Bukhari… - Journal of pharmaceutical innovation, 2021