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Background: Pancreatic cancer is one of the most lethal cancers in need of novel interventions. A role for dietary bioactive compounds in pancreatic cancer prevention is plausible because epidemiological studies indicate that consumption of fruits, vegetables, and cereal foods is associated with a lower risk of developing pancreatic cancer. Tocotrienols are bioactive components of cereal foods such as oats, barley, rice bran, and palm. These compounds have been demonstrated to have anticancer and chemopreventive activity in a wide variety of cancer types; however their activity in pancreatic cancer is unknown. In this study we investigated the comparative effects of the four natural tocotrienol compounds in order to determine the most bioactive tocotrienol against pancreatic cancer
 Methods: We first determined the anti-proliferative (MTT assay) and pro-apoptotic activity of α, β, γ and δ-tocotrienol in …