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Zaconeta et al (1) found that cerebrospinal uid (CSF) levels of CRH are higher among pregnant than among nonpregnant women. These results represent a substantial contribution to our understanding of pregnancy endocrinology. The authors also suggest that their study demonstrates a lack of association between the prenatal CSF CRH levels of women with vs without postpartum depression (PPD). This study, however, was not su ciently powered to assess this secondary question. Notably,