作者
Richard Rubenstein, Binggong Chang, John K Yue, Allen Chiu, Ethan A Winkler, Ava M Puccio, Ramon Diaz-Arrastia, Esther L Yuh, Pratik Mukherjee, Alex B Valadka, Wayne A Gordon, David O Okonkwo, Peter Davies, Sanjeev Agarwal, Fan Lin, George Sarkis, Hamad Yadikar, Zhihui Yang, Geoffrey T Manley, Kevin KW Wang, Shelly R Cooper, Kristen Dams-O’Connor, Allison J Borrasso, Tomoo Inoue, Andrew IR Maas, David K Menon, David M Schnyer, Mary J Vassar, TRACK-TBI Investigators
发表日期
2017/9/1
期刊
JAMA neurology
卷号
74
期号
9
页码范围
1063-1072
出版商
American Medical Association
简介
Importance
Annually in the United States, at least 3.5 million people seek medical attention for traumatic brain injury (TBI). The development of therapies for TBI is limited by the absence of diagnostic and prognostic biomarkers. Microtubule-associated protein tau is an axonal phosphoprotein. To date, the presence of the hypophosphorylated tau protein (P-tau) in plasma from patients with acute TBI and chronic TBI has not been investigated.
Objective
To examine the associations between plasma P-tau and total-tau (T-tau) levels and injury presence, severity, type of pathoanatomic lesion (neuroimaging), and patient outcomes in acute and chronic TBI.
Design, Setting, and Participants
In the TRACK-TBI Pilot study, plasma was collected at a single time point from 196 patients with acute TBI admitted to 3 level I trauma centers (<24 hours after injury) and 21 patients with TBI admitted to inpatient rehabilitation units (mean …
学术搜索中的文章
R Rubenstein, B Chang, JK Yue, A Chiu, EA Winkler… - JAMA neurology, 2017