作者
Lola Svensson, Annika K Hult, Robert Stamps, Jonas Ångström, Susann Teneberg, Jill R Storry, René Jørgensen, Lennart Rydberg, Stephen M Henry, Martin L Olsson
发表日期
2013/2/21
期刊
Blood, The Journal of the American Society of Hematology
卷号
121
期号
8
页码范围
1459-1468
出版商
American Society of Hematology
简介
In analogy with histo-blood group A antigen, Forssman (Fs) antigen terminates with α3-N-acetylgalactosamine and can be used by pathogens as a host receptor in many mammals. However, primates including humans lack Fs synthase activity and have naturally occurring Fs antibodies in plasma. We investigated individuals with the enigmatic ABO subgroup Apae and found them to be homozygous for common O alleles. Their erythrocytes had no A antigens but instead expressed Fs glycolipids. The unexpected Fs antigen was confirmed in structural, serologic, and flow-cytometric studies. The Fs synthase gene, GBGT1, in Apae individuals encoded an arginine to glutamine change at residue 296. Gln296 is present in lower mammals, whereas Arg296 was found in 6 other primates, > 250 blood donors and Apae family relatives without the Apae phenotype. Transfection experiments and molecular modeling …
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L Svensson, AK Hult, R Stamps, J Ångström… - Blood, The Journal of the American Society of …, 2013