作者
Neil D Avent, Antonio Martinez, Willy A Flegel, Martin L Olsson, Marion L Scott, Núria Nogués, Martin Písǎcka, Geoff Daniels, Ellen Van Der Schoot, Eduardo Muñiz‐Diaz, Tracey E Madgett, Jill R Storry, Sigrid H Beiboer, Petra A Maaskant‐van Wijk, Inge Von Zabern, Elisa Jiménez, Diego Tejedor, Mónica López, Emma Camacho, Goedele Cheroutre, Anita Hacker, Pavel Jinoch, Irena Svobodova, Masja De Haas
发表日期
2007/7
来源
Transfusion
卷号
47
页码范围
40S-46S
出版商
Blackwell Publishing Inc
简介
Human blood group antigen expression is gov-erned by polymorphic variation in protein and carbohydrate structures that extend from the surface of the erythrocyte membrane. Carbohydrate-dependent antigens (in ABO, P1, H, LE, GLOB, and I systems) are variations in polysaccharide antennae attached to glycoprotein or glycolipid molecules. The genetic bases of carbohydrate-dependent blood groups are determined by variation in glycosyltransferase sequences expressed by erythroid (and other) cells, which affect the enzyme specificity or efficacy during polysaccharide synthesis within the Golgi compartment. 1 Protein-dependent antigens (in RH; KEL; FY; JK; GIL; CO; DO; MNS; CROM; DI; IN; CH/RG; KN; GE; LW; LU; OK; SC; YT; XG; JMH; RAPH; and XK systems) are caused predominantly by single-nucleotide polymorphisms (SNPs) in the structural genes encoding erythrocyte membrane proteins. 2 These …
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ND Avent, A Martinez, WA Flegel, ML Olsson, ML Scott… - Transfusion, 2007