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Previous studies have reported inter-individual variability in the dopamine (DA) response to stress. This variability might be related to individual differences in the vulnerability to experience the negative effect of stress.

To investigate whether personality traits as measured by the Revised NEO Personality Inventory explain variability in DA response to a psychosocial stress task.

Eleven healthy adults, mean age of 26 ± 3.87 underwent two Positron Emission Tomography (PET) scans using the dopamine D_2/3 agonist, [¹¹C]-(+)-PHNO under a control and stress condition. The Simplified Reference Tissue Model (SRTM) was used to obtain [¹¹C]-(+)-PHNO Binding Potential (BP_ND). Stress-induced DA response was indexed as a percent change in [¹¹C]-(+)-PHNO BP_ND between control and stress conditions. The regions of interest were defined into D₂-rich regions, which …