作者
Michael Böhm, Kazuomi Kario, David E Kandzari, Felix Mahfoud, Michael A Weber, Roland E Schmieder, Konstantinos Tsioufis, Stuart Pocock, Dimitris Konstantinidis, James W Choi, Cara East, David P Lee, Adrian Ma, Sebastian Ewen, Debbie L Cohen, Robert Wilensky, Chandan M Devireddy, Janice Lea, Axel Schmid, Joachim Weil, Tolga Agdirlioglu, Denise Reedus, Brian K Jefferson, David Reyes, Richard D'Souza, Andrew SP Sharp, Faisal Sharif, Martin Fahy, Vanessa DeBruin, Sidney A Cohen, Sandeep Brar, Raymond R Townsend, Ertan Akarca, Suhail Allaqaband, Eirini Andrikou, Jiro Aoki, Ahran Arnold, Herbert Aronow, Masahiko Asami, William Bachinsky, John Barton, Kyle Bass, Bryan Batson, Chris Bell, Barry Bertolet, Yvonne Bewarder, Karl Bihlmaier, Christian Binner, Jason Bloom, Benjamin Blossom, Somjot Brar, Angela Brown, Robert Burke, Martin N Burke, Michael Butler, William Calhoun, James Campbell, Steve Carroll, Neil Chapman, Craig Chasen, Shi-Chi Cheng, Beth Chia, Nishit Choksi, Jordana Cohen, Niall Connolly, Johanna Contreras, Ronan Cusack, George Dangas, Shukri David, Justin Davies, Juliane Dederer, Matthew Denker, Udo Desch, Matthaios Didangelos, Thomas Dienemann, Kyriakos Dimitriadis, Jean-François Dorval, John Estess, Sarah Fan, Karl Fengler, Lee Ferguson, Marat Fudim, Valentin Fuster, Fidel Garcia, Santiago Garcia, Alex Garton, Carl Gessler, Magdi Ghali, Bharat Gummadi, Amit Gupta, Antonio Gutierrez, Peggy Hardesty, Phillip Hartung, Walter H Haught, Yonghong Haun, Sara Hays, Wolfgang Helmreich, Douglas Hill, Ingrid Hopper, Yu Horiuchi, Satoshi Hoshide, James Howard, Wanda Ikeda, Fued Jan, Rajiv Jauhar, Desmond Jay, James Johnson, Thomas Johnston, Schuyler Jones, Susanne Jung, Theodoros Kalos, Mihar Kanitkar, Dennis Kannenkeril, Alexandros Kasiakogias, Samer Kazziha, Daniel Keene, Jayant Khitha, Hosei Kikushima, Taisei Kobayashi, Kota Komiyama, Takahiro Komori, John Kotter, Antonios Kouparanis, Joshua Krasnow, Saarraangan Kulenthiran, Sarwan Kumar, Philippe L'Allier, Phillip Laney, Lucas Lauder, Marc A Lavoie, Matthias Lerche, Elena Linesky, Nelson Little, Carl Lomboy, Jelena Lucic, Philipp Lurz, Shannon Lynch, Prakash Mansukhani, Katie McDuffie, Brian McGrath, Brent McLaurin, Ashley Meade, Perwaiz Meraj, Dominic Millenaar, Naing Moore, Fumiko Mori, Phillip Munch, James Murphy, Jennifer Murray, Aravinda Nanjundappa
发表日期
2020/5/2
期刊
The Lancet
卷号
395
期号
10234
页码范围
1444-1451
出版商
Elsevier
简介
Background
Catheter-based renal denervation has significantly reduced blood pressure in previous studies. Following a positive pilot trial, the SPYRAL HTN-OFF MED (SPYRAL Pivotal) trial was designed to assess the efficacy of renal denervation in the absence of antihypertensive medications.
Methods
In this international, prospective, single-blinded, sham-controlled trial, done at 44 study sites in Australia, Austria, Canada, Germany, Greece, Ireland, Japan, the UK, and the USA, hypertensive patients with office systolic blood pressure of 150 mm Hg to less than 180 mm Hg were randomly assigned 1:1 to either a renal denervation or sham procedure. The primary efficacy endpoint was baseline-adjusted change in 24-h systolic blood pressure and the secondary efficacy endpoint was baseline-adjusted change in office systolic blood pressure from baseline to 3 months after the procedure. We used a Bayesian …
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M Böhm, K Kario, DE Kandzari, F Mahfoud, MA Weber… - The Lancet, 2020