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Objective:

Adherence to antiretroviral therapies (ART) is the strongest predictor of viral suppression among individuals infected with HIV, however, limited data exists to understand the patterns of adherence that confer the greatest benefit across different ART regimens.

Design:

Longitudinal data pooled from 16 studies conducted between 1997 and 2009 across the United States.

Methods:

Adherence was measured using Medication Event Monitoring System. Percentage of time with sufficient drug concentrations (covered time) and the length of the longest treatment interruption during the 28 days prior to plasma HIV-RNA measurements were calculated. Logistic regression with generalized estimating equations was used to estimate medication-specific adherence estimates on detectable HIV-RNA (> 400 copies/ml).

Results:

One thousand and eighty-eight participants with 3795 HIV-RNA measures were studied. Both …