作者
S Ghosh, P More, A Derle, R Kitture, T Kale, M Gorain, A Avasthi, P Markad, GC Kundu, S Kale, DD Dhavale, J Bellare, B. A. Chopade
发表日期
2015
期刊
Journal of Nanoscience and Nanotechnology
卷号
15
页码范围
1-9
出版商
American Scientific Publishers
简介
Iron oxide nanoparticles (IONPs) have gained immense importance recently as drug nanocarriers due to easy multifunctionalization, simultaneous targeting, imaging and cancer hyperthermia. Herein, we report a novel nanomedicine comprising of IONPs core functionalized with a potent anticancer bioactive principle, diosgenin from medicinal plant Dioscorea bulbifera via citric acid linker molecule. IONPs were synthesized by reverse co-precipitation and characterized using field emission scanning electron microscopy (FESEM), high resolution transmission electron microscopy (HRTEM) and dynamic light scattering (DLS). Diosgenin functionalization was confirmed using fourier transform infrared spectroscopy (FTIR) and biochemical methods. Synthesized IONPs, citrate linked IONPs (IONPs-CA), diosgenin functionalized IONPs (IONPs-D) along with free citric acid and diosgenin were checked for anticancer activity …
学术搜索中的文章
S Ghosh, P More, A Derle, R Kitture, T Kale, M Gorain… - Journal of Nanoscience and Nanotechnology, 2015