查看文章

In the “big data era”, the amount of digital information is growing explosively, therefore, a reliable data storage medium for large-scale digital archiving is urgently needed. However, the increase of existing storage capacity cannot keep up with the growth of digital information. Moreover, the durability of conventional storage technologies, such as magnetic and optical devices, is very limited. Since the first demonstration of using DNA to store messages in 1988, DNA has been considered as a promising data storage medium due to its high-density and long-term stability (half-life> 500 years)(Allentoft et al., 2012). Although some studies have developed information storage strategies using synthetic DNA, the difficulty, cost, and error rate of information extraction is relatively high owing to ternary or binary system based digital encoding method, which consequently limited their application (Church et al., 2012; Goldman et al., 2013). Therefore, we developed a platform with a novel encoding scheme to store digital information utilizing DNA synthesis and next-generation sequencing (NGS) technologies.