作者
Andrea S Les, Shawn C Shadden, C Alberto Figueroa, Jinha M Park, Maureen M Tedesco, Robert J Herfkens, Ronald L Dalman, Charles A Taylor
发表日期
2010/4
期刊
Annals of biomedical engineering
卷号
38
页码范围
1288-1313
出版商
Springer US
简介
Abdominal aortic aneurysms (AAAs) affect 5–7% of older Americans. We hypothesize that exercise may slow AAA growth by decreasing inflammatory burden, peripheral resistance, and adverse hemodynamic conditions such as low, oscillatory shear stress. In this study, we use magnetic resonance imaging and computational fluid dynamics to describe hemodynamics in eight AAAs during rest and exercise using patient-specific geometric models, flow waveforms, and pressures as well as appropriately resolved finite-element meshes. We report mean wall shear stress (MWSS) and oscillatory shear index (OSI) at four aortic locations (supraceliac, infrarenal, mid-aneurysm, and suprabifurcation) and turbulent kinetic energy over the entire computational domain on meshes containing more than an order of magnitude more elements than previously reported results (mean: 9.0-million elements; SD: 2.3 M; range …
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