作者
M Kristen Demoruelle, Michael H Weisman, Philip L Simonian, David A Lynch, Peter B Sachs, Isabel F Pedraza, Annie R Harrington, Jason R Kolfenbach, Christopher C Striebich, Quyen N Pham, Colin D Strickland, Brian D Petersen, Mark C Parish, Lezlie A Derber, Jill M Norris, V Michael Holers, Kevin D Deane
发表日期
2012/6
期刊
Arthritis & Rheumatism
卷号
64
期号
6
页码范围
1756-1761
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Objective
To evaluate the presence of pulmonary abnormalities in rheumatoid arthritis (RA)–related autoantibody–positive subjects without inflammatory arthritis.
Methods
Forty‐two subjects who did not have inflammatory arthritis but were positive for anti–cyclic citrullinated peptide antibodies and/or ≥2 rheumatoid factor isotypes (a profile that is 96% specific for RA), 15 autoantibody‐negative controls, and 12 patients with established seropositive early RA (<1‐year duration) underwent spirometry and high‐resolution computed tomography (HRCT) lung imaging.
Results
The median age of autoantibody‐positive subjects was 54 years, 52% were female, and 38% were ever‐smokers; these characteristics were not significantly different from those of autoantibody‐negative control subjects. No autoantibody‐positive subject had inflammatory arthritis based on joint examination. HRCT revealed that 76% of …
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MK Demoruelle, MH Weisman, PL Simonian, DA Lynch… - Arthritis & Rheumatism, 2012