作者
Altan Ercan, Jing Cui, Dereck EW Chatterton, Kevin D Deane, Melissa M Hazen, William Brintnell, Colin I O'Donnell, Lezlie A Derber, Michael E Weinblatt, Nancy A Shadick, David A Bell, Ewa Cairns, Daniel H Solomon, V Michael Holers, Pauline M Rudd, David M Lee
发表日期
2010/8
期刊
Arthritis & Rheumatism
卷号
62
期号
8
页码范围
2239-2248
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Objective
To examine the association between aberrant IgG galactosylation and disease parameters in rheumatoid arthritis (RA).
Methods
Analysis of N‐glycan in serum samples from multiple cohorts was performed. The IgG N‐glycan content and the timing of N‐glycan aberrancy relative to disease onset were compared in healthy subjects and in patients with RA. Correlations between aberrant galactosylation and disease activity were assessed in the RA cohorts. The impact of disease activity, sex, age, anti–cyclic citrullinated peptide (anti‐CCP) antibody titer, disease duration, and C‐reactive protein level on aberrant galactosylation was determined using multivariate analysis. The N‐glycan content was also compared between epitope affinity–purified autoantibodies and the remaining IgG repertoire in RA patients.
Results
Our results confirm the aberrant galactosylation of IgG in RA patients as compared with …
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A Ercan, J Cui, DEW Chatterton, KD Deane, MM Hazen… - Arthritis & Rheumatism, 2010